Prague, Czech Republic, October 4-7, 2017

Scientific Program

Carolinum auditorium of Charles University, Prague, the oldest university on the European continent. Charles University was founded April 7, 1348 by Charles IV, King of Bohemia and Holy Roman Emporer, making it one of the oldest universities of the world. The ET-15 Welcome Reception will be held at the Carolinum.

Wednesday, October 4, 2017

15.00-17.00 Registration

18.00-20.00 Welcome Reception
Carolinum Hall, Charles University

Thursday, October 5, 2017

Venue: Hotel Duo, Prague

Morning Session

8.00-10.00 Symposium I

Endothelin signaling and mechanisms of endothelin action

Chairs: Pedro d´Orleans-Juste, Augusto C. Montezano

8.00-8.30 Key Note Lecture
Pharmacology of Endothelin Receptors: Prospects for the Next Decade
Anthony P. Davenport, University of Cambridge, UK

10.00-10.30 Coffee Break

Symposium II

Pharmacology, new drugs and drug interactions

Chairs: Janet Maguire, Anil Gulati

10.30-11.00 Key Note Lecture
Pharmacological Interventions Targeting the Endothelin Pathway: the Status Quo and Future Perspectives
Noriaki Emoto, Kobe Pharmaceutical University, Japan

12.00-12.15 ET-15 Conference Group Photograph

12.15-14.00 Lunch and Poster Session

Afternoon Session

14.00-15.30 Symposium III

Physiology and pathophysiology of cardiovascular function

Chairs: Noriaki Emoto, Pavel Jansa

14.00-14.30 Key Note Lecture
Endothelin in Resistance Artery Responses of Patients With Cardiovascular Disease
Jo De Mey, University of Odense, Denmark

15.30-16.00 Coffee Break

Symposium IV

Pulmonary function and pulmonary hypertension

Chairs: Martine Clozel, Vladimir Tesař

16.00-16.30 Key Note Lecture
Advances in Pathophysiology and Treatment of Chronic Pulmonary Hypertension
Pavel Jansa, Charles University, Czech Republic

18.00-21.00 Young Investigator Event

Friday, October 6, 2017

Morning Session

Symposium V

Metabolism, diabetes, metabolic syndrome, and obesity

Chairs: John Pernow, Carmine Cardillo

8.00-8.20 Invited Lecture
Bitter Taste of Diabetic Complications: Endothelin
Adviye Ergul, Augusta University, U.S.A.

8.20-8.40 Invited Lecture
Novel Aspects on Metabolism and Hypertension – The Nitrate-Nitrite-NO Pathway
Eddie Weitzberg, Karolinska Institutet, Sweden

10.00-10.30 Coffee Break

Symposium VI

Physiology and pathophysiology of renal function

Chairs: Neeraj Dhaun, Ivana Vaněčková

10.30-10.50 Invited Lecture
Endothelin Receptor Antagonism and Kidney Disease
Donald E. Kohan, University of Utah, U.S.A.

10.50-11.20 Invited Lecture
Endothelin and the Kidney Clock
David M. Pollock, University of Alabama, U.S.A.

12.00-14.00 Lunch and Poster Session

Afternoon Session

Symposium VII

Sex differences in physiology and disease

Chairs: Jennifer S. Pollock, Hiromi Yanagisawa

14.00-14.30 Key Note Lecture
The Interplay Between Endothelin-1 and Testosterone in the Activation of the Immune System
Rita C. Tostes, University of Sao Paulo, Brazil

15.30-16.00 Coffee Break

Symposium VIII

Neurophysiology, neurobiology, dementia and pain

Chairs: Adviye Ergul, Jo De Mey

16.00-16.30 Key Note Lecture
ETB Receptors Agonist, IRL-1620, for the Treatment of CNS Disorders
Anil Gulati, Midwestern University, U.S.A.

16.30-17.00 Key Note Lecture
A Genetic Variant Associated with Five Vascular Diseases is a Distal Regulator of Endothelin-1 Expression
Rajat M. Gupta, Harvard Medical School, Boston, USA

19.30 Pre-Banquet Reception

20.00 Concert and Conference Banquet

Saturday, October 7, 2017

Morning Session

Symposium IX

Immune system and inflammation

Chairs: Ariela Benigni, Josef Zicha

8.30-8.30 Key Note Lecture
Immune Mechanisms in Hypertension
Ernesto L. Schiffrin, McGill University, Montréal, Canada

10.00-10.30 Coffee Break

Symposium X

Cancer and metastasis

Chairs: Laura Rosano, Marilena Loizidou

10.30-11.00 Key Note Lecture
Targeting ET-1 Receptor/-Arrestin1 Signaling Circuit in Ovarian Cancer Treatment
Anna Bagnato, Regina Elena National Cancer Institute, Italy

11.30 - 12.30 Lunch

Afternoon Session

Symposium XI:
Role of endothelin in selected diseases

Chairs: David M. Pollock, Pierre-Louis Tharaux

12.30-13.30 Key Note Lecture
Balloon Angioplasty and Endothelin
Matthias Barton, University of Zurich, Switzerland

14.00-14.30 Coffee Break

Symposium XII:
Endothelin receptor antagonists in clinical trials

Chairs: David J. Webb, Věra Čertíková Chábová

14.30-14.55 Invited Lecture
From Endothelin Research to Drugs
Martine Clozel, Actelion, Switzerland

14.55-15.20 Invited Lecture
Dual Angiotensin II (Ang II) AT1 and Endothelin (ET) Type A Receptor Inhibition With Sparsentan in Primary Focal Segmental Glomerulosclerosis (FSGS): DUET Trial
Radko Komers, Retrophin, U.S.A.

15.20-15.45 Invited Lecture
Endothelin Antagonists in the Treatment of Diabetic Nephropathy – An Update
Vladimir Tesař, Charles University, Czech Republic

Award Ceremony
The Fourth Tomoh Masaki Award (2017)
Awards for best oral and best poster presentations

Highlights of ET-15
Special Lecture: Masashi Yanagisawa, University of Tsukuba, Japan

16.30-16.40 Closing remarks by the Conference Chairs
Ivana Vaněčková, Czech Academy of Sciences, Czech Republic
John Pernow, Karolinska Institutet, Sweden