Cambridge, England, September 11-14, 2011

The First Tomoh Masaki Award (2011)

Masashi Yanagisawa, UT Southwestern Dallas and University of Tsukuba, received the inaugural Tomoh Masaki Award.1

Click on link below to open access article on The First Tomoh Masaki Award (2011) including
historical information about the award's name holder and the awardee.

ET-12 Young Investigator Awards

The ET-12 Young Investigator Award was presented to investigators aged 35 and younger in recognition of the excellence of research presented at ET-12. A total number of 35 awards was presented to young investigators from 11 countries. Bambang Widyantoro (far right), after ET-10 and ET-11, was awarded an Young Investigator Award
for the third time in a row at an endothelin conference.

Click on link below to open access article on the role of young investigators in endothelin research

Christopher Adlbrecht
Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Austria
Systemic endothelin receptor blockade in acute ST-segment elevation acute coronary syndrome protects the microvasculature - a pilot study

Hilda Ahnstedt
Clinical Sciences, Experimental Vascular Research, Lund University, Sweden
Differential effects of Raf inhibitors on upregulation of contractile endothelin B receptors in rat cerebral arteries after organ culture

Johny Al-Khoury
Anatomy and Cell Biology, University of Sherbrooke, Canada
Modulation of release of Endothelin-1 in hypertrophic human endocardial and vascular endothelial cells

Caroline Archer
The Babraham Institute, and University of Cambridge, Department of Pharmacology, United Kingdom
Signalling requirements for ET-1-Induced hypertrophy

Nur Arfian
Kobe University Graduate School of Medicine, Cardiovascular Division Internal Medicine, Kobe, Japan
Endothelial cell derived endothelin-1 knockdown attenuates kidney fibrosis via reducing peritubular capillary loss and pericyte to myofibroblast transition

Levon Avedanian
Anatomy and Cell Biology, University of Sherbrooke,Sherbrooke, Canada
ET-1 modulates tubular and reticular structures in the nucleus

Oliver Baretella
Department of Pharmacology & Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China
Endothelial overexpression of endothelin-1 augments endothelium-dependent contractions in the mouse carotid artery

Simona Buelli
Mario Negri Institute for Pharmacological Research, Bergamo, Italy
Endothelin(ET)-1, via ETA receptor, activates β-arrestin-mediated signaling pathways and promotes podocyte migration in vitro: possible implications for proliferative lesions in chronic kidney disease

Ruha Cerrato
Department of Medicine, Cardiology Unit, Karolinska Institute, Stockholm, Sweden
Endothelin-1 increases superoxide production in human coronary artery bypass grafts

Mila Cervar-Zivkovic
Medical University, ObGyn, Graz, Austria
Endothelin/endothelin receptor system is upregulated in preeclampsia with or without fetal growth restriction in contrast to gestational diabetes

Karolina Duthie
Centre for Cardiovascular Science, University of Edinburgh, United Kingdom
Selective Endothelin A receptor antagonism attenuates neointimal lesion development in the mouse femoral artery

Samer-ul Haque
Department of Surgery, University College London, United Kingdom
Endothelin-1 stimulated gene induction within colon cancer cells and fibroblasts and the effect of endothelin receptor antagonism on key genes

Anggoro Budi Hartopo
Cardiovascular Division, Internal Medicine,Kobe University Graduate School of Medicine, Kobe, Japan
Endothelin converting enzyme-1 genetic inhibition prevents bleomycin-induced pulmonary fibrosis in mice

Susi Heiden
Cardiovascular Division, Internal Medicine,Kobe University Graduate School of Medicine, Kobe, Japan
Anti-TNF-α therapy ameliorates cardiac function in mice with reduced endogenous endothelin-1 and increased afterload

Martin Houde
Département de Pharmacologie, Université de Sherbrooke, Canada
Mouse mast cell protease 4 generates endothelin-1 in vitro and in vivo

Kelly Hyndman
Dept of Medicine,Georgia Health Sciences University, United States.
Mouse inner medullary collecting duct-3 cell NO production is regulated by ET-1, but NOS1 and NOS3 expression are not

Mollie Jacobs
Biochemistry and Molecular Biology, University of Florida, Gainesville, United States
Post-transcriptional regulation of edn1 mRNA in kidney collecting duct cells

Mary Leonard
Chicago College of Pharmacy, Midwestern University, Downers Grove, United States
Endothelin B agonist, IRL-1620, reduces neurological damage following cerebral ischemia in rats

Lowell Ling
Clinical Pharmacology,Department of Medicine, University of Cambridge, United Kingdom
Endothelin receptors in normal and cirrhotic human liver

Merlijn Meens
Pharmacology, Maastricht University,The Netherlands
Arterial anti-endothelinergic effects of calcitonin gene-related peptide in vitro and in vivo

Clémence Merlen
Montreal Heart Institute, Canada
Signalling pathways mediated by endothelin receptors located at the nuclear membrane

Matthias Meyer
Department of Cell Biology and Physiology, UNM Health Sciences Center, Albuquerque, United States
Novel role of G protein-coupled estrogen receptor GPER/GPR30 as a regulator of intracellular calcium concentration during endothelin-1-induced arterial vasoconstriction

Jelly Nelissen
Maastricht University, Pharmacology,The Netherlands
Endothelin-1 and calcitonin gene-related peptide are both involved in hypertension; evidence from 2 experimental models of hypertension

Karla Neves
Pharmacology, University of Sao Paulo, Brazil
The adipokine chemerin increases vascular reactivity to ET-1 via activation of ERK1/2

Hemanshu Patel
Cardiovascular Research, Dept Clinical Research, University of Bern, Switzerland
Dendritic cell regulation of endothelin-1 by endogenous toll like receptor ligands: implications for autoimmune disease

Daniel Reed
National Heart and Lung Institute, Imperial College London, United Kingdom
Endothelin-1 release from endothelial cells from blood vessels compared with those derived from stem cell sources

Monika Schlosser
Pathology, University of Cologne, Germany
Endothelin-1 dependent complex formation resulting in p16INK4a gene regulation

Amit Shah
Neuroscience, Michigan State University, United States.
Endothelin B receptor activation in postganglionic sympathetic neurons causes hyper-responsiveness to acetylcholine that is dependent on reactive oxygen species

Gregory Star
Lady Davis Institute, Jewish General Hospital McGill University, Montreal, Canada
Knockdown of bone morphogenic protein receptor–II by siRNA increases in vitro endothelin-1 synthesis by human pulmonary microvascular endothelial cells

Yoko Suzuki
Clinical Pharmacy, Kobe Pharmaceutical University, Kobe, Japan
Potentiating bradykinin pathway by genetic suppression of endothelin-converting enzyme-1 prevented hypoxic induced pulmonary hypertension and right ventricular hypertrophy

Jonathan Towler
QMRI, University of Edinburgh, United Kingdom
What is the best method of proteinuria measurement in clinical trials of antiproteinuric drugs?

Nicolas Vignon-Zellweger
Cardiovascular Division, Internal Medicine,Kobe University Graduate School of Medicine, Kobe, Japan
The ET-1 / Endothelin A receptor axis for the integrity of the glomerular filtration barrier under diabetes in mice

Melanie von Brandenstein
Pathology, University of Cologne, Germany
Protein kinase C α regulates nuclear primicroRNA15a release as part of Endothelin signaling

Alison Whyteside
University of Leeds, United Kingdom
Molecular mechanisms regulating ECE-1 expression in prostate cancer

Bambang Widyantoro
Cardiovascular Division, Internal Medicine,Kobe University Graduate School of Medicine, Kobe, Japan
Endothelial cell-derived endothelin-1 promotes cardiac lipid accumulation in diabetic heart

Three generations of successful mentoring: Kobe University Young Investigator Award recipients of the group of Noriaki Emoto, Kobe University, who is also shown together with his mentor, Masashi Yanagisawa1

ET-12 Awards for Best Presentation

The newly established ET-12 Awards for the Best Presentation in the oral presentation and poster category both went
to Melanie von Brandenstein, University of Koeln, Germany, shown here with ET-12 Honorary Chair Masashi Yanagisawa.
Melanie von Brandenstein also received an ET-12 Young Investigator Award.

"The Future of Endothelin Research" and ET-12 Conference Chairs Matthias Barton and Anthony Davenport

(1Photographs courtesy of Suzete Sandin, Sherbrooke, Canada)