Rome, Italy, October 11-14, 2023
Conference Program
Wednesday, October 11, 2023
17:00-18:00: Registration
18:00-20:00: Welcome Reception
Thursday, October 12, 2023
8:50-9:00 Opening Remarks
Carmine Cardillo, Catholic University of the Sacred Heart, Rome, Italy
Neeraj Dhaun, University of Edinburgh, Edinburgh, UK
Francesca Schinzari, Policlinico Gemelli IRCCS, Rome, Italy
9:00-11:10 SESSION I - ENDOTHELIN TARGETING IN ONCOLOGY
Session Chairs:
Pedro D’Orleans-Juste, Université de Sherbrooke, Sherbrooke, Canada
Janet Maguire, University of Cambridge, Cambridge, UK
9:00-9:30 Opening Lecture
Recent advances in drugs acting on the ET-1 system
Anthony Davenport, University of Cambridge, Cambridge, UK
9:30-10:00 Key Note Lecture
Role of the endothelin system in cancer-supporting phenotypic alterations
Rajkumar Savai, Liebig University, Giessen, Germany
10:00-10:15
The intersection of the endothelin-1 receptor axis with mechanical cues affects PARP inhibitor response in highgrade serous ovarian cancer
P. Tocci, Rome, Italy
10:15- 10:30
Regulation of invasion and peritoneal dissemination of serous ovarian cancer by Endothelin A receptor and Integrin ꞵ interplay
I. Masi, Rome, Italy
10:30-10:45
Preclinical immunotherapeutic approaches to treat tumors overexpressing endothelin receptors
D. Boquet, Gif-Sur-Yvette, France
10:45-11:10 Invited Lecture
Identification of new therapeutic vulnerabilities in cancer exploiting the molecular ET-averse
Anna Bagnato, Regina Elena National Cancer Institute, Rome, Italy
11:10-11:30 Coffee break
11:30-13:15 SESSION II - ENDOTHELIN ANTAGONISM IN HYPERTENSION
Session Chairs:
David Webb, The Queen Medical’s Research Institute, Edinburgh, Scotland
Ivana Vaneckova, Czech Academy of Sciences, Prague, Czech Republic
11:30-12:00 Key Note Lecture
Non-selective ET receptor antagonism in resistant hypertension: the PRECISION trial
Ernesto Schiffrin, McGill University, Montreal, Canada
12:00-12:15
Evidence for endothelin regulation of the suprachiasmatic nucleus – the master circadian clock
D. Pollock, Birmingham, USA
12:15-12:30
Hypertension Worsens Endothelin-1-Mediated Vasoconstrictor Tone in Adults with Obesity
A. Berry, Boulder, USA
12:30-12:45
Environmental Enrichment after Ischemic Stroke Decreases Brain Endothelin -1 (ET-1) and ETA Receptor Expression in Spontaneously Hypertensive Rats
Y. Abdul, Charleston, USA
12:45-13:15 Special Lecture
Nitric Oxide
Louis J. Ignarro, Los Angeles, USA
Nobel Prize in Physiology or Medicine 1998
13:15-14:15 Lunch
14:15-15:15 Poster Session 1
Chairs:
Jennifer Pollock, University of Alabama, Birmingham, USA
Michelle Gumz, University of Florida, Gainesville, USA
15:15-16:45 SESSION III - ENDOTHELIN AND NEUROLOGICAL DISORDERS
Session Chairs:
Rita Tostes, University of Sao Paulo, Sao Paulo, Brazil
Kelly Hyndman, University of Alabama at Birmingham, Birmingham, USA
15:15-15:45 KeyNote Lecture
Effects of endothelin-1 on the brain microvasculature
Adviye Ergul, Medical University of South Carolina, Charleston, USA
16:45-16:00
Sovateltide, a neural progenitor cell therapeutic for the treatment of acute ischemic stroke, shows no effect on the thrombolytic activity of t-PA
M. Lavhale, Greater Noida, India
16.00-16:15
Role of Sovateltide Mediated Agonism of Endothelin B Receptors in Regeneration and Repair in the Adult Brain after Ischemic Stroke
A. Ranjan, Willowbrook, USA
16:15-16:30
Intranasal inhibition of brain endothelin receptor A (ETA) exerts positive effects on cognitive functions in a hypoperfusion model of VCID in diabetic rats
Y. Abdul, Charleston, USA
16:30-17:00 Invited Lecture
Advances in the treatment of neurologic disorders using drugs active on the endothelin system
Anil Gulati, Midwestern University of Illinois, Chicago, USA
Friday October 13, 2023
9:00-11:00 SESSION IV - RECENT ACQUISITIONS IN THE TREATMENT OF KIDNEY DISEASE
Session Chairs:
Ariela Benigni, Mario Negri Institute, Bergamo, Italy
David Pollock, University of Alabama, Birmingham, USA
9:00-9:30 Key Note Lecture
Review of recent clinical trials with drugs targeting the ET-1 system
Hiddo Lambers Heerspink, University Medical Center, Groningen, The Netherlands
09:30-09:45
First-line treatment with sparsentan, a dual endothelin and angiotensin receptor antagonist, in patients with immunoglobulin A nephropathy: initial results of the SPARTAN study
M. Sayer, Edinburgh, UK
09:45-10:00
Endothelium-derived endothelin-1 mediates sickle cell inflammation and nephropathy
J. Pollock, Birmingham, USA
10:00-10:15
Endothelin A receptor antagonist promotes iron recycling in murine models of iron overload
M. Kasztan, Birmingham, USA
10:15-10:45 Invited Lecture
Is there a role of ET antagonism for nephroprotection in the era of SGLT2 or mineralcorticoid receptor inhibition?
Pierre-Louis Tharaux, Centre de Recherche Cardiovasculaire, Paris, France
10:45-11:05 Coffee break
11:20-13:15 SESSION V - CARDIOLOGY
Session Chairs:
John Pernow, Karolinska Institutet, Stockholm, Sweden
Rajat Gupta, Harvard Medical School, Boston, U.S.A.
11:05-11: 35 Key Note Lecture:
Could targeting the endothelin system become a suitable approach in HFpEF?
Kieran Daugherty, University of Glasgow, Glasgow, Scotland
11:35-11:50
Endothelin mediates communication between heart and skeletal muscle during heart failure
S. Das, Baltimore, USA
11:50-12:05
Endothelin-1 Impairs the Capacity of Brain Endothelial Cells to Release Tissue-Type Plasminogen Activator
A. Berry, Boulder, USA
12:05 p.m. 12:20 p.m.
Dissecting endothelin-dependent functional responses in human cardiac organoids to identify new heart failure targets
S. Foster, Herston, Australia
12:20-12:55 Invited Lecture
Endothelin in coronary artery diseases
Matthias Barton, University of Zurich, Zurich, Switzerland
12:55-13:15 Hot Topic Presentation
Mandibulofacial dysostosis with alopecia resulting from ETAR gain-of-function
Y. Kurihara, Unviersity of Tokyo, Tokyo, Japan
13:15-14:00 Lunch
14:00-15:00 Poster Session 2
Chairs:
Ivana Vaneckova, Czech Academy of Sciences, Prague, Czech Republic
Kelly Hyndman, University of Alabama, Birmingham, U.S.A.
15:00-16:45 SESSION VI - ENDOCRINOLOGY AND METABOLISM
Session Chairs:
Manfredi Tesauro, Tor Vergata University, Rome, Italy
Jo De Mey, University of Maastricht, Maastricht, Netherlands
15:00-15:30 Key Note Lecture
Role of ET-1 in the oxidative stress associated with diabetic vasculopathy
Rhian Touyz, McGill University, Montreal, Canada
15:30-15:45
Adipocyte specific ETB receptor knockout attenuates insulin resistance and dyslipidemia in mice fed high fat diet
J. Speed, Jackson, USA
15:45-16:00
Loss of Endothelin-2 Impairs Early-Stage Adipocyte Differentiation
P. Rinastiti, Kobe, Japan
16:00-16:15
Endothelin-1 promotes perivascular adipose tissue dysfunction in obese mice via Nrf2 downregulation and oxidative stress
R. Tostes, Ribeirão Preto, Sao Paolo, Brazil
16:15-16:45 Invited Lecture
Role of endothelin and endothelin antagonism in non-alcoholic fatty liver degeneration (NALFD)
Wilhelmus Kwanten, University of Antwerp, Antwerp, Belgium
Saturday October 14, 2023
9:00-10:45 SESSION VII - PNEUMOLOGY AND RHEUMATOLOGY
Session Chairs:
Pedro D’Orleans-Juste University of Sherbrooke, Sherbrooke, Canada
Carmine Cardillo, Catholic University, Rome, Italy
9:00-9:30 Key Note Lecture
Update on the use of ET-1 antagonists in pulmonary hypertension
Noriaki Emoto. Kobe Pharmaceutical University, Kobe, Japan
09:30-09:45
Dapagliflozin and ambrisentan co-administration in patients hospitalised with COVID-19. A report from mulTiArm therapeutiC sTudy in pre-Icu patients admitted with Covid-19 – Experimental drugs and mechanisms (TACTIC-E)
P. Ambery, AstraZeneca, Göteborg, Sweden
09:45-10:00
Acute amelioration of inflammatory activity caused by endothelin-2 deficiency during acute lung injury
A. Musthafa, Kobe, Japan
10:00-10:15
Targeting endothelin signalling for combating SARS-CoV-2induced osteochondral defect
M. T. Au, Hong Kong
10:15-10:45 Invited Lecture
Role of ET-1 in vasculitis
Neeraj Dhaun, University of Edinburgh, Edinburgh, Scotland
10:45-11:05 Coffee Break
11:05-12:50 SESSION VIII - DERMATOLOGY AND WOMEN’S HEALTH
Session Chairs:
Matthias Barton, University of Zurich, Zurich, Switzerland
Donald E. Kohan University of Utah, Salt Lake City, USA
11:05-11:35 Key Note Lecture
ET-1 and hair follicle regeneration
Michael Rendl, Icahn School of Medicine at Mount Sinai, New York, USA
11:35-11:50
Serum endothelin-1 increased in Indonesian hypertensive females: The result of Sleman HDSS populational survey
A. B. Hartopo, Yogyakarta, Indonesia
11:50-12:05
Leptin is a novel upregulator of placental endothelin-1 in preeclampsia
J. Faulkner, Augusta, USA
12:05-12:20
Sex-specific role for the clock protein PER1 in the regulation of renal ET-1 in salt-sensitive hypertension
M. Gumz, Gainesville, USA
12:20-12:50 Invited Lecture
Role of ET-1 in pre-eclampsia
Jan Danser, Erasmus University, Rotterdam, The Netherlands
12:50-13:35 Lunch
13:35-14:45 Round Table Discussion
Endothelin targeting: where are we going?
Moderator and Session Chair:
Donald E. Kohan, Salt Lake City, Utah, USA
Panelists:
Phillip Ambery, Göteborg, Sweden
Noriaki Emoto, Kobe, Japan
Martine Clozel, Allschwil, Switzerland
Anil Gulati, Downers Grove, USA
Bruce Hendry, London, UK
Ike Ogbaa, Leverkusen, Germany
Pierre-Louis Tharaux, Paris, France
David Webb, Edinburgh, UK
14:45-15:15 Award Ceremony
15:15-15:45 ET-18 Highlights
Masashi Yanagisawa, University of Tsukuba, Tsukuba, Japan
15:45-16:00 Closing remarks by the Conference Chairs
16:00-16.30 End of the Conference