Tokyo, Japan, September 8-11, 2013


Scientific Program



Click here for the ET-13 program book


Sunday, 8. September 2013


Evening

18:00-20:00 Welcome Reception

Tokyo Dome Hotel, Tokyo, Japan




Monday, 9. September 2013


University of Tsukuba, Tokyo Campus

Opening of the ET-13 Conference


Noriaki Emoto, Kobe University
Takashi Miyauchi, University of Tsukuba

8:30-9:44 Opening Remarks by the Conference Chairs


Morning Sessions

8:40-9:10 Session 1 - New Aspects of Endothelin in Physiology and Disease

Chairs: Pedro D'Orléans-Juste, Sherbrooke University, Montreal, Canada
Soichi Miwa, Hokkaido University, Sapporo, Japan

Invited lecture: Interaction and Sexual Dimorphism of ETB/NOS Signaling in Cardiovascular and Renal Disease
Jennifer Pollock, Georgia Regents University, Augusta, USA

Invited lecture: Endothelin is Getting Older: How Aging Links Endothelin with Disease
Matthias Barton, University of Zurich, Switzerland

Oral presentations:

Development of Osteoarthritis-like Changes in Transgenic Endothelin-1 Over-expressed Mice
Chunyi Wen, University of Hong Kong, Hong Kong, China

Characterisation Of the "Endothelin-Like Domain Peptide" (ELDP) Co-synthesised With Endothelin-1 from the EDN1 gene.
Jale Yuzugulen, Queen Mary University of London, London, UK


9:45-10:30 Session 2 - Oncology

Chairs: Anna Bagnato, Regina Elena National Cancer Institute, Rome, Italy
Marilena Loizidou, University College, London, UK

Keynote lecture: The Endothelin Axis: a New Player in Tumor Angiogenesis and Lymphangiogenesis
Francesca Spinella Regina Elena National Cancer Institute, Rome, Italy

Oral presentations

Endothelin-1 Induced Mxi-2/Ago2 Complex Formation Resulting in p53 Downregulation Promoting Breast Cancer Development
Melanie von Brandenstein, University of Cologne, Cologne, Germany

Tamoxifen Treatment in Breast Cancer Induces a Cytoplasmic Complex Consisting of Endothelin-1, Estrogen Receptors, and Tamoxifen Leading to Nuclear Transmigration, and Transcription of Target Genes Involved in Metastatic Spread
Julia Straube, University of Rhein-Bonn-Sieg, Sankt Augustin, Germany

10:30-10:55 Coffee break


10:55-12:05 Session 3 - Renal Diseases

Chairs: David Pollock, Georgia Regents University, Augusta, USA
Neeraj Dhaun, University of Edinburgh, UK

Keynote lecture: The Role of Endothelin in Glomerular Diseases: Cellular Culprits, Cellular Targets
Pierre-Louis Tharaux, University Paris-Descartes, Paris, France

Oral presentations

Heterozygous Overexpression of Preproendothelin-1 in Endothelial Cells Enhances Thromboxane-Prostanoid Receptor-Induced Contractions in the Renal Artery of Obese Mice
Oliver Baretella, University of Hong Kong, Hong Kong, China

The Effect of Proteinuria-Mediated Endothelin-1 Downregulation of PKCα Signalling in Proximal Tubular Cells and Its Successul Treatment is Measurable Using MicroRNA15a as Biomarker in Vitro and in Vivo
Heike Loeser, University Hospital Cologne, Cologne, Germany

ET-B Receptors in Podocytes Promote Diabetic Glomerulosclerosis with β-catenin and NFκB Activation
Olivia Lenoir, Paris Cardiovascular Research Centre (INSERM), Paris, France

Changes in Urinary ET-1 Excretion in Response to Increased Renal Perfusion Pressure in the Rat
Geoff J. Culshaw, The Queens Medical Research Institute, Edinburgh, UK


12:05-12:15 Break


Afternoon Sessions

12:15-13:15 Lunch Session 1

Chair: Keiko Takihara, Osaka University, Suita, Japan

Recent Progress in the Management of Pulmonary Arterial Hypertension
Speaker: Hiroshi Watanabe, Hamamatsu University, Hamamatsu, Japan
Co-sponsor: Pfizer Japan Inc.


13:15-13:45 Lunch Session 2

Chair: Kazutaka Aonuma, University of Tsukuba, Tsukuba, Japan

Medical Treatment for Type Diabetes Mellitus for Inhibiting Vascular Events
Speaker: Toyoaki Murohara, Nagoya University, Nagoya, Japan
Co-sponsor: MSD K.K.


14:15-14:45 Poster Session 1

Poster titles and presenter information are available
here


14:45-15:35 Session 4 - Resistant Hypertension

Chairs: Kazutaka Aonuma, University of Tsukuba, Tsukuba, Japan
Anthony Davenport, University of Cambridge, UK

Invited lecture: Treatment-Resistant Hypertension: The Challenges for Drug Treatment
David Webb, University of Edinburgh, UK

Invited lecture: Impact of Neuromodulation on Pressure Dysregulation -from Hypertension to Hypotension-
Kenji Sunagawa, Kyushu University, Hakata, Japan

15:35-16:05 Coffee break


16:05-17:05 Session 5 - Neurology, Pain, and Stroke

Chair: Anil Gulati, Midwestern University, Chicago, USA
Yasuo Matsumura, Osaka University, Japan

Invited lecture: Targeting Endothelin Axis to Treat Pain
Anil Gulati, Midwestern University, Chicago, USA

Oral presentations

Endothelin B Receptor Agonist, IRL-1620, Enhances Neurovascular Remodeling Following Cerebral Ischemia in Rats
Mary G. Leonard, Midwestern University, Downers Grove, USA

Endothelin Receptor A as a Modulator of Photoreceptor Signaling
Vicente Bermudez, Universidad Austral, Argentina

Endothelin-1 Treatment Induces Experimental Cerebral Malaria During Plasmodium Berghei NK65 Infection
Yuri C. Martins, Albert Einstein College of Medicine, New York, USA


17:05-17:45 Session 6 - Actual Applications and Future Perspectives of Dual ETA/ETB Antagonists

Chairs: Janet Maguire, University of Cambridge, UK
Ariela Benigni, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy

Invited lecture: Benefits of Dual Endothelin Receptor Antagonists: Mechanisms of Action, Current Studies, and Future Directions
Martine Clozel, Actelion, Switzerland

Invited lecture: Effects of Bosentan on Digital Ulcers in Patients with Systemic Sclerosis
Yasushi Kawaguchi, Tokyo Women's Medical University




Tuesday, 10. September 2013


University of Tsukuba, Tokyo Campus


Morning Sessions

8:30-10:10 Session 7 - Gene Regulation, Molecular and Cellular Biology

Chairs: Keiichi Fukuda, Keio University, Tokyo, Japan
Chemyong Ko, University of Illinois, Chicago, USA

Invited lecture: Tissue-Specific and Time-Dependent Regulation of the Endothelin Axis by the Circadian Clock Protein Per1
Michelle Gumz, University of Florida, Gainsville, USA

Invited lecture: Endothelin Signaling in Craniofacial and Cardiac Development
Hiroki Kurihara, The University of Tokyo, Tokyo, Japan

Oral presentations

Erythropoietin Induced Blood Pressure Rise, Vascular Inflammation and Oxidative Stress in Mice Overexpressing Human Endothelin-1: Improvement by Exercise
Pierre Paradis, McGill University, Montreal, Canada

Endothelin-1-Induced Oxidative Stress and Inflammatory Cell Infiltration Contribute to High-Fat Diet Induced-Atherosclerosis and Aneurysm Formation in Apolipoprotein E Knockout Mice
Pierre Paradis, McGill University, Montreal, Canada

Flow Regulation of Inner Medullary Collecting Duct Endothelin-1 Production
Meghana M. Pandit, University of Utah Health Sciences Center, Salt Lake City, USA

Ubiquitin Modification Plays an Important Role in ET-1-Dependent Endothelin Type B Receptor Trafficking
Koji Terada, Hokkaido University, Sapporo, Japan

Aldosterone Alters Chromatin Structure of the Murine Endothelin-1 Gene
Amanda K. Welch, University of Florida, Gainsville, USA

10:20-10:40 Coffee break


10:40-12:06 Session 8 - Pulmonary Hypertension

Chairs: Masaaki Ito, Mie University, Tsu, Japan
Toru Satoh Kyorin, University, Tokyo, Japan

Keynote lecture: The Evolving Paradigm of Pulmonary Arterial Hypertension and the Evolving Role of Endothelin-1
David Langleben, McGill University, Montreal, Canada

Invited lecture: Balloon Pulmonary Angioplasty as a Treatment Option for Chronic Thromboembolic Pulmonary Hypertension
Hiromi Matsubara, National Hospital Organization, Okayama, Japan

Oral presentations

Adipose-Derived Regenerative Cells Therapy Improves Monocrotaline Induced Rat Pulmonary Arterial Hypertension with Suppressing Endothelin-1 though an Anti-Inflammatory Mechanism
Masamichi Eguchi, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Role of Bradykinin and Endothelin-Converting Enzyme-1 in Pulmonary Hypertension
Sunu B. Raharjo, University of Indonesia, Jakarta, Indonesia

Long-Term Survival in Japanese Patients with Idiopathic/Heritable Pulmonary Arterial Hypertension
Aiko Ogawa, National Hospital Organization Okayama Medical Center, Okayama, Japan


12:06-12:15 Break


Afternoon Sessions

12:15-13:15 Lunch Session 3

Chair: Tsutomu Saji Toho University, Tokyo, Japan

Twenty-five years of research leading to a new generation of endothelin receptor antagonists
Speaker: Martine Clozel, Actelion, Switzerland
Co-sponsor: Actelion Pharmaceuticals Japan Ltd.

12:15-13:15 Lunch Session 4

Chairs: Yoshihide Asano, The University of Tokyo, Tokyo, Japan
Masaru Hatano, The University of Tokyo, Tokyo, Japan

The Roles of Endothelin Receptor Antagonists and Phosphodiesterase Type 5 Inhibitors in the Management of Skin Ulcers in Systemic Sclerosis
Speaker: Yoshihide Asano, The University of Tokyo, Tokyo, Japan
Co-sponsor: Nippon Shinyaku Co., Ltd.

The Challenge to Refractory Pulmonary Hypertension Associated with Scleroderma
Speaker: Masaru Hatano, The University of Tokyo, Tokyo, Japan
Co-sponsor: Nippon Shinyaku Co., Ltd.


13:15-14:45 Poster Session 2

Poster titles and presenter information are available
here


14:45-16:05 Session 9 - Blocking the ETA Receptors: What's New?

Chairs: Michael Dashwood, University College, London, UK
Ernesto Schiffrin, McGill University, Montreal, Canada

Invited lecture: Endothelin Receptor Selectivity in Patients with Pulmonary Arterial Hypertension (PAH)
Ron Oudiz, University of California, Los Angeles, USA

Invited lecture: Age-Dependent Antihypertensive and Antiproteinuric Effects of ETA Receptor Blockade in Ren-2 Transgenic Rats
Ivana Vaněčková, Institute of Physiology, Prague, Czech Republic

Invited lecture: Dual Endothelin A and Angiotensin Receptor Blockers in the Treatment of Hypertension and Renal Disease
Donald Kohan, University of Utah, Salt Lake City, USA

Invited lecture: Good and Bad News about Single and Dual Biphenyl ETA/AT1 Antagonists

Jo De Mey, University of Southern Denmark, Odense, Denmark

16:05-16:30 Coffee break


16:30-16:45 Young Investigator Award Ceremony


16:45-17:15 Honorary Chair Session

Chair: Hiroaki Shimokawa, Tohoku University, Sendai, Japan

Invited lecture: End o' the Line Revisited
Paul Vanhoutte, Li Ka Shing Faculty of Medicine, Hong Kong, China


17:15-17:45 Special Guest Session

Chair: Masashi Yanagisawa, UT Southwestern Medical Center Dallas, USA / University of Tsukuba, Japan

Invited lecture: Multiple and Integrative Approaches to Cardiovascular Diseases with Stem Cell Technology
Jun Yamashita, Kyoto University, Kyoto, Japan

18:15-21:30 Celebration for the 25th Anniversary of the Discovery of Endothelin, Conference Dinner




Wednesday, 11. September 2013


University of Tsukuba, Tokyo Campus


Morning Sessions

8:30-10:00 Session 10 - Cardiology, Hypertension, Vascular Disease

Chairs: Rita Tostes, University of São Paulo, Brazil
Jo De Mey, University of Southern Denmark, Odense, Denmark

Keynote lecture: Endothelin in Myocardial Infarction
Theofilos Kolettis, University of Ioannina, Greece

Oral presentations

Endothelin-1 is a Key Candidate to Exert Pathophysiological Effects on Cardiomyocytes Derived from Hypertrophic Cardiomyopathy-Induced Pluripotent Stem Cell
Atsushi Tanaka, Keio University School of Medicine, Tokyo, Japan

Endothelin Receptor Antagonists Exacerbate Autoimmune Myocarditis in Mice
Kazuko Tajiri, University of Tsukuba, Tsukuba, Japan

Imaging of the Binding of ET-1 and of Linear ET-1 in Rat Mesenteric Resistance Arteries
Dimitrios Kapsokalyvas, Maastricht University, Maastricht, The Netherlands

Sympathetic endothelin A receptors contribute to the development of heart failure
Johannes P. Backs, Heidelberg University, Heidelberg, Germany

Mouse Mast Cell Protease-4-Dependent Production of ET-1 (1-31) and of Plaque Progression in a Apolipoprotein E Knock-Out Mouse Model of Spontaneous Atherosclerosis.
Martin Houde, Sherbrooke University, Montreal, Canada

10:00-10:30 Coffee break


10:30-12:05 Session 11 - Clinical Studies Update

Chairs: John Pernow Karolinska Institutet, Stockholm, Sweden
Issei Komuro, The University of Tokyo, Tokyo, Japan

Keynote lecture: Endothelin Receptor Antagonists in Clinical Research - Lessons Learned
Berthold Hocher, University in Potsdam, Germany

Invited lecture: Endothelin Receptor Antagonism Versus Combined ECE/NEP Inhition in Patients with Type 2 Diabetes and Nephropathy
Ariela Benigni, IRCCS, Bergamo, Italy

Invited lecture: The Selective Type A Endothelin Antagonist Atrasentan Reduces Residual Albuminuria in Patients with Type 2 Diabetes and Nephropathy
Dennis Andress, Abbvie, USA

Invited lecture: A Placebo-Controlled Study of Ambrisentan in Subjects with Idiopathic Pulmonary Fibrosis (ARTEMIS-IPF)
Hunter Gillies, Gilead, USA

Oral presentations

Impact of Short Term Endothelin A Receptor Blockade on Plasma Markers for Remodeling and Neutrophil Activation in Patients with ST Elevation Acute Coronary Syndrome
Raphael Wurm, Medical University of Vienna, Vienna, Austria


12:05-12:15 Break

Afternoon Sessions

12:15-13:15 Lunch Session 5

Chair: Yasuo Matsumura, Osaka University of Pharmaceutical Sciences, Osaka, Japan

Heart Failure in PAH: Focus on the Right Ventricle
Speaker: Ron Oudiz, University of California, Los Angeles, USA
Co-sponsor: GlaxoSmithKline K.K.

12:00-13:00 Lunch Session 6

Chair: Shigetake Sasayama, Kyoto University, Kyoto, Japan

How to Treat the Patients with Hypertension for the Prevention of Heart Diseases-the Back and Forth Strategy between Basic Science and Clinical Medicine
Speaker: Masafumi Kitakaze, National Cerebral and Cardiovascular Center, Suita, Japan
Co-sponsor: Takeda Pharmaceutical Company Limited.


13:15-14:45 Poster Session 3

Poster titles and presenter information are available
here


14:45-15:45 Session 12 - Metabolism, Diabetes and Obesity

Chairs: Adviye Ergul, Georgia Regents University, Augusta, USA
Subrata Chakrabrati, University of Western Ontario, Canada

Keynote lecture: Role of Endothelin in Vascular Dysfunction in Human Obesity and Diabetes
Carmine Cardillo, Catholic University of Rome, Italy

Oral presentations

Molecular Mechanism for Suppression of Insulin Signaling by Endothelin-1 in Skeletal Muscle Cells.
Takahiro Horinouchi, Hokkaido University, Sapporo, Japan

Plasma endothelin-1 level is associated with cardiac fibrosis and diastolic dysfunction in diabetes
Bambang Widyantoro, University of Indonesia, Jakarta, Indonesia

Activation of ET-1-Mediated PKC-Epsilon/ERK1/2 Pathway Contributes to the Augmented Contractile Response in Aorta from Young Obese Rats
Fernando P. Filgueira, University of São Paulo, Ribeirão Preto, Brazil

15:45-16:15 Coffee break


16:15-16:30 Tomoh Masaki Award Ceremony
Best Presentation and Best Poster Awards Ceremony


16:30-17:00 Session 13 - Highlights of ET-13
Speaker: Masashi Yanagisawa, Southwestern Medical Center Dallas, USA


17:00-17:15 Closing remarks by the Conference Chairs



Noriaki Emoto, Kobe University
Takashi Miyauchi, University of Tsukuba